Vaccinated Rat and Human Heart Cell Study Shows How Hearts Get Damaged

ER Editor: Dr. Peter McCullough also examines this new study. See —

Direct Cardiac Effects of mRNA-Based SARS-CoV-2 Vaccines

Of note:

This means that mRNA coding for foreign protein is taken up by heart cells and it makes them sick with abnormalities of contraction and electrical conduction. This is very bad news for all mRNA products. If heart muscle cells cannot be excluded from biodistribution of mRNA, this means every new mRNA vaccine could cause heart problems including cardiac arrest.

This and many studies support a complete moratorium on mRNA research given these very serious findings. I called for that moratorium on a national interview in August, 2023.


Vaccinated Rat and Human Heart Cell Study Shows How Hearts Get Damaged

Rat experiments that should have been done before injecting humans


In a new laboratory research letter, scientists from the Giessen Institute of Physiology (Germany) and the National Heart Laboratory of Semmelweis University (Hungary) finally were able to pinpoint some mechanisms of how Covid vaccines damage hearts.

Before I go on, I want to thank our paying subscribers: their monetary contributions allowed me to purchase the full research letter paywalled by the British Journal of Pharmacology. Substack subscriptions allow my reports to go beyond headlines and free abstracts, as I purchase full versions of many non-free articlesMy selfless paying subscribers get no perks or benefits (other than my heartfelt thanks): no paid-only commenting, no paid-only content, and so on.

So, if you are a free subscriber, please thank our paying subscribers (and consider upgrading your subscription, but only if you can afford it).

The paywalled peer-reviewed study is here:

… this study investigated the effect of mRNA-1273 and BNT162b2 on the function, structure, and viability of isolated adult rat cardiomyocytes over a 72h period.

Key Results

In the first 24h after application, both mRNA-1273 and BNT162b2 caused neither functional disturbances nor morphological abnormalities. After 48h, expression of the encoded spike protein was detected in ventricular cardiomyocytesfor both mRNAs. At this point in time, mRNA-1273 induced arrhythmic as well as completely irregular contractions associated with irregular as well as localized calcium transients, which provide indications of significant dysfunction of the cardiac ryanodine receptor (RyR2).

In contrast, BNT162b2 increased cardiomyocyte contraction via significantly increased protein kinase A (PKA) activity at the cellular level.

Conclusions and Implications

Here we demonstrated for the first time, that in isolated cardiomyocytes, both mRNA-1273 and BNT162b2 induce specific dysfunctions that correlate patho-physiologically to cardiomyopathy. Both RyR2 impairment and sustained PKA activation may significantly increase the risk of acute cardiac events.

What This Study Adds

We already know, based on cardiac damage markers in humans, that COVID vaccines cause heart damage, sometimes hidden, that is far from rare:

Igor’s Newsletter

COVID Vaccines Damage ALL Hearts, Study Finds

A new scientific study by Nakahara et al. tested COVID-vaccinated people to see if they have “silent” changes in heart muscle function that standard radiology tests could detect. The study shows very unsettling results. Scientists measured myocardial 18Fluorine-fluorodeoxyglucose (18F-FDG) uptake. F-FDG has molecular similarity to glucose. However, 18F-F…
Read more

What is not as clear is: what exactly does happen to the hearts that raises biomarkers of damage?

Since scientists cannot remove and slice the hearts of living humans, the mechanism of this damage remains mysterious. It does not help that the FDA, Pfizer, and Moderna refuse to release data from follow-up myocarditis studies.

The German/Hungarian study we are reviewing contributes a detailed, in-vitro laboratory analysis of what exactly happens to heart muscle cells (cardiomyocytes) under conditions typical for a recipient of COVID vaccines.

The authors, Schreckerberg et al., first refer us to a biodistribution study that measured the concentration of COVID vaccines in the hearts of Wistar lab rats after vaccination. The scientists applied the same concentrations to the heart cells of young male rats, as well as human heart cells:

In this study, the amount of mRNA used was calculated from the lipid concentration detected in the rat heart 2h after injection of 50μg [3H]-labeled LNP mRNA

Scientists used cell cultures to conduct an experiment unaffected by the many complications of testing the hearts of living organisms. They had proper control groups – Petri dishes with heart cells that did not receive the mRNA injection.

The heart cells, called cardiomyocytes, underwent deleterious changes after in-vitro “vaccination.” Compared to the control group, the vaccinated heart cells malfunctioned in various ways:

The authors explain how both vaccines damage heart muscle cells:

Immune Reaction was Excluded by Design!

Much of the discussion of “myocarditis” involves hypotheses of the heart being damaged by our body’s immune rejection of heart cells.

The Schreckerberg study we are discussing purposely excluded such immune reactions because it used cell cultures without any immune cells. And yet, they detected deleterious effects on heart cells (cardiomyocytes). There are more causes of heart damage than immune reactions could explain, authors show by excluding any immune-related factor.

We must appreciate the authors’ intent to concentrate on one particular aspect of vaccination.

The Authors Make a Strong Anti-Vaccine Conclusion!

The times are changing! Here’s the most amazing part, rarely seen in peer-reviewed studies published in official journals. The authors do not mince words and say we must re-evaluate giving people mRNA vaccines due to their cardiotoxic effects!

As I said many times, this Substack blog is not anti-science. This is a pro-good-science publication, always eager to highlight honest research, which often puts the authors’ careers at risk for speaking the truth.

I appreciate the elegant study by the German and Hungarian scientists, although I wish this research had been done before billions of people were poisoned. Sadly, little will change now – but the truth is finally coming out.

Do you think “science” will ever focus on helping vaccine-injured people, or will it continue to gaslight and ignore them?




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