ER Editor: We also recommend this piece we ran from RT in April titled Fecal transplants yield a MASSIVE breakthrough for child autism, 50% reduction in severity (VIDEO). This report references a medical study that we are linking to directly here: Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
Readers may also be interested in this publication by the doctor cited below from 2017, Dr. Eran Elinav, titled The remedy within: will the microbiome fulfill its therapeutic promise?
Clinics offering this therapy are rather thin on the ground; to our knowledge, certain countries only offer this therapy through their health services for people who have a prior history of C.difficile infections. We can recommend the Taymount Clinic in the UK, which offers this type of treatment privately.
Please note that ER receives no payment nor any other kind of benefit for making this recommendation.
Animal research finds potential gut microbiome help for ALS
Scientists in Israel believe that intestinal microbiomes may affect the course of ALS. The discovery of the possible effects of “the gut microbiome” could eventually benefit people affected by Lou Gehrig’s disease.
The findings “suggest that, in the future, various means of altering the microbiome may be harnessed for developing new therapeutic options for ALS,” said immunology professor Eran Elinav, who led the study.
Affected mice struggled to survive in germ-free conditions, in which they carried no microbiome. Results hinted at a link between microbiome alterations and disease progression in mice created to be genetically susceptible to ALS, which is also known as Lou Gehrig’s Disease.
Step by step
The scientists characterized the composition and function of the microbiome in the mice who were engineered to be susceptible to ALS, comparing them against mice who had not been genetically tampered with. They identified 11 microbial strains that became altered in the mice made prone to ALS as the disease progressed — or even before they developed overt symptoms of it.
Scientists administered strains individually in probioticlike supplements to susceptible mice following antibiotics and found that some strains had a negative impact on ALS. One strain, Akkermansia muciniphila, significantly slowed disease progression in the mice and prolonged their survival.
Scientists then examined molecules secreted by gut microbes, zeroing in on nicotinamide (NAM). NAM levels in the mice’s blood and in cerebrospinal fluid dipped following antibiotic treatment and increased after scientists administered them Akkermansia, which could secrete this molecule.
Finally, the researchers examined the microbiome and metabolite profiles of 37 human ALS patients and compared them with those of family members sharing the same household. A detailed genomic analysis suggested that the ALS patients had distinct gut microbiomes in composition and functional features from those of healthy controls.
Read more: Does gut flora cause multiple sclerosis?
When the researchers tested the levels of NAM itself, they found them significantly reduced in both the blood and the brains of 60 human ALS patients when compared with the control group. Moreover, they found a correlation between reduced NAM levels and the degree of muscle weakness in the patients.
mkg/jm (Weizmann Institute of Science)
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